diff --git a/CHANGES b/CHANGES
index fe3c9c2970..de6ff35539 100644
--- a/CHANGES
+++ b/CHANGES
@@ -1,3 +1,7 @@
+4698.	[port]		Add --with-python-install-dir configure option to allow
+			specifying a nonstandard installation directory for
+			Python modules. [RT #45407]
+
 4697.	[bug]		Restore workaround for Microsoft Windows TSIG hash
 			computation bug. [RT #45854]
 
diff --git a/bin/python/Makefile.in b/bin/python/Makefile.in
index 18d2135b4c..cfc7c7fe65 100644
--- a/bin/python/Makefile.in
+++ b/bin/python/Makefile.in
@@ -53,9 +53,9 @@ install:: ${TARGETS} installdirs
 	${INSTALL_DATA} ${srcdir}/dnssec-keymgr.8 ${DESTDIR}${mandir}/man8
 	if test -n "${PYTHON}" ; then \
 		if test -n "${DESTDIR}" ; then \
-			${PYTHON} ${srcdir}/setup.py install --root=${DESTDIR} --prefix=${prefix} ; \
+			${PYTHON} ${srcdir}/setup.py install --root=${DESTDIR} --prefix=${prefix} @PYTHON_INSTALL_LIB@ ; \
 		else \
-			${PYTHON} ${srcdir}/setup.py install --prefix=${prefix} ; \
+			${PYTHON} ${srcdir}/setup.py install --prefix=${prefix} @PYTHON_INSTALL_LIB@ ; \
 		fi ; \
 		rm -rf build ; \
 	fi
diff --git a/bin/python/dnssec-checkds.py.in b/bin/python/dnssec-checkds.py.in
index 32e20026f6..420e862c43 100644
--- a/bin/python/dnssec-checkds.py.in
+++ b/bin/python/dnssec-checkds.py.in
@@ -12,8 +12,11 @@ import sys
 
 sys.path.insert(0, os.path.dirname(sys.argv[0]))
 if os.name != 'nt':
-    sys.path.insert(1, os.path.join('@prefix@', 'lib',
-		    'python' + sys.version[:3], 'site-packages'))
+    if '@PYTHON_INSTALL_DIR@': # value of --with-python-install-dir
+        sys.path.insert(1, '@PYTHON_INSTALL_DIR@')
+    else:
+        sys.path.insert(1, os.path.join('@prefix@', 'lib',
+                        'python' + sys.version[:3], 'site-packages'))
 
 import isc.checkds
 
diff --git a/bin/python/dnssec-coverage.py.in b/bin/python/dnssec-coverage.py.in
index 6b7dfa422d..ef546b1141 100644
--- a/bin/python/dnssec-coverage.py.in
+++ b/bin/python/dnssec-coverage.py.in
@@ -12,8 +12,11 @@ import sys
 
 sys.path.insert(0, os.path.dirname(sys.argv[0]))
 if os.name != 'nt':
-    sys.path.insert(1, os.path.join('@prefix@', 'lib',
-		    'python' + sys.version[:3], 'site-packages'))
+    if '@PYTHON_INSTALL_DIR@': # value of --with-python-install-dir
+        sys.path.insert(1, '@PYTHON_INSTALL_DIR@')
+    else:
+        sys.path.insert(1, os.path.join('@prefix@', 'lib',
+                        'python' + sys.version[:3], 'site-packages'))
 
 import isc.coverage
 
diff --git a/bin/python/dnssec-keymgr.py.in b/bin/python/dnssec-keymgr.py.in
index 1caa6922b4..82d1c8a18a 100644
--- a/bin/python/dnssec-keymgr.py.in
+++ b/bin/python/dnssec-keymgr.py.in
@@ -12,8 +12,11 @@ import sys
 
 sys.path.insert(0, os.path.dirname(sys.argv[0]))
 if os.name != 'nt':
-    sys.path.insert(1, os.path.join('@prefix@', 'lib',
-		    'python' + sys.version[:3], 'site-packages'))
+    if '@PYTHON_INSTALL_DIR@': # value of --with-python-install-dir
+        sys.path.insert(1, '@PYTHON_INSTALL_DIR@')
+    else:
+        sys.path.insert(1, os.path.join('@prefix@', 'lib',
+                        'python' + sys.version[:3], 'site-packages'))
 
 import isc.keymgr
 
diff --git a/configure.in b/configure.in
index f2fcf7ea7c..4d422998cf 100644
--- a/configure.in
+++ b/configure.in
@@ -212,6 +212,10 @@ AC_SUBST(PERL)
 AC_ARG_WITH(python,
 [  --with-python=PATH      specify path to python interpreter],
     use_python="$withval", use_python="unspec")
+AC_ARG_WITH(python-install-dir,
+	    AC_HELP_STRING([--with-python-install-dir=PATH],
+			   [installation directory for Python modules]),
+	    use_python_install_dir="$withval", use_python_install_dir="unspec")
 
 python="python python3 python3.5 python3.4 python3.3 python3.2 python2 python2.7"
 
@@ -268,8 +272,19 @@ case "$use_python" in
                                         unset PYTHON
 				fi
 			done
-			if test "X$PYTHON" = "X"
+			if test "X$PYTHON" != "X"
 			then
+				case "$use_python_install_dir" in
+				unspec)
+					PYTHON_INSTALL_DIR=""
+					PYTHON_INSTALL_LIB=""
+					;;
+				*)
+					PYTHON_INSTALL_DIR="$use_python_install_dir"
+					PYTHON_INSTALL_LIB="--install-lib=$use_python_install_dir"
+					;;
+				esac
+			else
 				AC_MSG_CHECKING([for python support])
 				case "$use_python" in
 				unspec)
@@ -327,6 +342,8 @@ AC_SUBST(CHECKDS)
 AC_SUBST(COVERAGE)
 AC_SUBST(KEYMGR)
 AC_SUBST(PYTHON_TOOLS)
+AC_SUBST(PYTHON_INSTALL_DIR)
+AC_SUBST(PYTHON_INSTALL_LIB)
 
 #
 # Special processing of paths depending on whether --prefix,