diff --git a/CHANGES b/CHANGES
index 0033a48809..547d93876c 100644
--- a/CHANGES
+++ b/CHANGES
@@ -1,3 +1,6 @@
+4369.	[bug]		Fix 'make' and 'make install' out-of-tree python
+			support. [RT #42484]
+
 4368.	[bug]		Fix a crash when calling "rndc stats" on some
 			Windows builds because some Visual Studio compilers
 			generated crashing code for the "%z" printf()
diff --git a/bin/python/Makefile.in b/bin/python/Makefile.in
index 899193d490..0f647e3fea 100644
--- a/bin/python/Makefile.in
+++ b/bin/python/Makefile.in
@@ -53,7 +53,7 @@ install:: ${TARGETS} installdirs
 	${INSTALL_SCRIPT} dnssec-coverage ${DESTDIR}${sbindir}
 	${INSTALL_DATA} ${srcdir}/dnssec-checkds.8 ${DESTDIR}${mandir}/man8
 	${INSTALL_DATA} ${srcdir}/dnssec-coverage.8 ${DESTDIR}${mandir}/man8
-	test -z "${PYTHON}" || ${PYTHON} setup.py install --prefix=${DESTDIR}${prefix}
+	test -z "${PYTHON}" || ${PYTHON} ${srcdir}/setup.py install --prefix=${DESTDIR}${prefix}
 
 clean distclean::
 	rm -f ${TARGETS}
diff --git a/bin/python/isc/tests/Makefile.in b/bin/python/isc/tests/Makefile.in
index f865cee792..1fdf3f98e4 100644
--- a/bin/python/isc/tests/Makefile.in
+++ b/bin/python/isc/tests/Makefile.in
@@ -26,7 +26,7 @@ PYTESTS =	dnskey_test.py
 
 check test:
 	for test in $(PYTESTS); do \
-		$(PYTHON) $$test; \
+		PYTHONPATH=${srcdir}/../.. $(PYTHON) ${srcdir}/$$test; \
 	done
 
 clean distclean::